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MGP matrix Gla protein [Homo sapiens (human)] - Gene - NCBI
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Description:Data suggest that an SNP in promoter region of matrix Gla protein rs1,,; TC is associated with diabetic angiopathy as indicated by carotid intima media thickness in patients with type 2 diabetes and diabetic nephropathy. Dp-ucMGP was high preoperatively, and further increased postoperatively in cardiovascular risk patients. Studied serum levels of bone morphogenic protein-4 BMP-4 and matrix Gla protein MGP in patients who were admitted to emergency department with the diagnosis of acute coronary syndrome ACS and underwent primary percutaneous coronary intervention. Increased desphospho-uncarboxylated matrix Gla protein, which is a circulating biomarker of vitamin K status and vascular calcification, is independently associated with aortic stiffness, but not with stiffness of distal muscular-type arteries. Matrix Gla protein TC polymorphism is associated with carotid intima media thickness and predicts mortality in patients with diabetic nephropathy.
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